This article explores the relation between the concept of symmetry and its formalisms. The standard view among philosophers and physicists is that symmetry is completely formalized by mathematical groups. For some mathematicians however, the groupoid is a competing and more general formalism. An analysis of symmetry that justifies this extension has not been adequately spelled out. After a brief explication of how groups, equivalence, and symmetries classes are related, we show that, while it’s true in some instances that groups are (...) too restrictive, there are other instances for which the standard extension to groupoids is too un restrictive. The connection between groups and equivalence classes, when generalized to groupoids, suggests a middle ground between the two. *Received July 2007. †To contact the authors, please write to: Alexandre Guay, UFR Sciences et Techniques, Université de Bourgogne, 9 Avenue Alain Savary, 21078 Dijon Cedex, France; e‐mail: [email protected] ; or to Brian Hepburn, Department of Philosophy, University of British Columbia, 1866 Main Mall E370, Vancouver, BC, Canada V6T 1Z1; e‐mail: [email protected]. (shrink)

Here is a phrase never uttered before: ”Euler’s philosophy of science.” Known as an extraordinary mathematician first, a mathematical physicist Known as an extraordinary mathematician first, a mathematical physicist second, but never really a physicist — not enough empirical cred — no one has considered whether Euler had a philosophy of science. Even his famed “Letters to a Princess” is described as a somewhat naive parroting of New- ton. But Euler is no Newtonian. His philosophy of science borrows from Leibniz, (...) a little from Descartes, but is best seen as continuous with the tradition of a Galilean interpre- tation of the world as consisting of interacting mechanisms, and the practice of letting the requirements of sound mechanical description and problem solving dictate metaphysics. (shrink)

A key theme in the historiographical work of Machamer has been the ways that motion is made intelligible through explanatory means of natural motion and models of the simple machines such as the lever and pendulum. One way of spelling out the explanatory value of these strategies is through the concept of equilibrium. Natural motion and simple machines allow the simplification of complex problems in terms of self-evident, intelligible equilibrium conditions. This chapter connects the theme of equilibrium and natural motion (...) across Machamer’s work on mechanisms and mechanical explanation, on Aristotle, Galileo, Descartes and Newton, and on the pendulum and mental models. Just as equilibrium can be found within science, it also becomes a model of intelligibility for doing history and philosophy of science: a normative but objective representation of the important properties of science. (shrink)

I criticize Shimony's argument from the Transient Now (Shimony 1993) that the B-series view of time is inadequate but offer a reading of that argument that is more charitable than one offered and rejected by Eilstein (1996). Shimony's argument turns on putative phenomenological features of the Now (singularity and numerical identity) but transience only arises as a logical implication of those features. Transience is thus a second order phenomenon. If these two features are accurate then the B-series cannot provide a (...) complete account of the Now and Eilstein misses the role of Shimony's Phenomenological Principle (PP) in this regard. Holding a B-theoretic view then demands giving up the numerical identity of person-slices across time. (shrink)

Euler’s ‘On the force of percussion and its true measure’, published in 1746, shows that not only had the issue of vis viva not been settled, but that the concepts of inertia and even force were still very much up for grabs. This paper details Euler’s treatment of the vis viva problem. Within those details we find differences between his physics and that of Newton, in particular the rejection of empty space and reduction of all forces to the operation of (...) inertia through contact. One can further see how Euler’s philosophy of science embraced explanation through mechanisms and equilibrium conditions.Keywords: Leonhard Euler; Vis viva; Equlibrium; Mechanics; Eighteenth century. (shrink)

1. Overview and organizing themes 2. Historical Review: Aristotle to Mill 3. Logic of method and critical responses 3.1 Logical constructionism and Operationalism 3.2. H-D as a logic of confirmation 3.3. Popper and falsificationism 3.4 Meta-methodology and the end of method 4. Statistical methods for hypothesis testing 5. Method in Practice 5.1 Creative and exploratory practices 5.2 Computer methods and the ‘third way’ of doing science 6. Discourse on scientific method 6.1 “The scientific method” in science education and as seen (...) by scientists 6.2 Privileged methods and ‘gold standards’ 6.3 Scientific method in the court room 6.4 Deviating practices 7. Conclusion Bibliography Academic Tools Other Internet Resources Related Entries . (shrink)

An intuitive and appealing way to characterize problem solving is as the application of constraints which reduce the problem-solution space. Any advantage offered by interdisciplinary problem solving would then plausi- bly derive from the integration of constraints from the fields involved. We propose an account of interdisciplinary problem solving which treats the integration of constraints as an iterative process. Appealing to a general- ization of entity-activity dualism from mechanical explanation, we extend the accounts of Bechtel and of Craver to non-hierarchical, (...) non-life-science, interdisciplinary problem-solving. Integration of disciplines occurs at the level of fields and their explanatory frameworks. (shrink)

In support of a recent conjecture by Nielsen (1999), we prove that the phenomena of ‘incomparable entanglement’— whereby, neither member of a pair of pure entangled states can be transformed into the other via local operations and classical communication (LOCC)—is a generic feature when the states at issue live in an infinite-dimensional Hilbert space.  2002 Elsevier Science B.V. All rights reserved.

Scientific Change How do scientific theories, concepts and methods change over time? Answers to this question have historical parts and philosophical parts. There can be descriptive accounts of the recorded differences over time of particular theories, concepts, and methods—what might be called the shape of scientific change. Many stories of scientific change attempt to give […].

Chalmers’s anti-materialist argument runs as follows.

An earlier version of this paper was presented at the 2011 IEEE International Symposium on Technology and Society at Saint Xavier University in Chicago, Illinois. We propose a cooperative approach by students in recording lecture activities such that the classroom becomes more visually accessible for everyone, especially for deaf, hard of hearing and low-vision students. Students utilize their personal camera-equipped smart phones to capture and share their views of a visually inaccessible classroom to students' devices. We show this approach virtually (...) retrofits a classroom to make it a more visually accessible learning environment. This approach can be used in meetings to get and share optimal views of the meeting for all participants. (shrink)

Tomasello argues in the target article that a sense of moral obligation emerges from the creation of a collaborative “we” motivating us to fulfill our cooperative duties. We suggest that “we” takes many forms, entailing different obligations, depending on the type of the relationship in question. We sketch a framework of such types, functions, and obligations to guide future research in our commentary.

The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)

Why pursue economic growth? For poor countries this is an easy question to answer, but it is more difficult for rich ones. Some of the world's greatest philosophers and economists – such as John Stuart Mill, John Maynard Keynes, and John Rawls – thought that, once a certain material standard of well-being has been achieved, economic growth should stop. I argue the opposite in this article. We always have reason to pursue economic growth. My argument is indirect. I shall not (...) argue that economic growth itself is always better. Rather, I shall argue that stopping growth requires morally objectionable actions. Economic growth tends to occur naturally if certain underlying conditions are in place. We have moral reasons to insist on these conditions independent their effect on growth, however. Halting growth requires that we alter these conditions, but we ought not do this. (shrink)

(2009). Mellow Monday and furious Friday: The approach-related link between anger and time representation. Cognition & Emotion: Vol. 23, No. 6, pp. 1166-1180.

We use data collected among Hadza hunter-gatherers between 2005 and 2009 to examine hypotheses about the causes and consequences of men’s foraging and food sharing. We find that Hadza men foraged for a range of food types, including fruit, honey, small animals, and large game. Large game were shared not like common goods, but in ways that significantly advantaged producers’ households. Food sharing and consumption data show that men channeled the foods they produced to their wives, children, and their consanguineal (...) and affinal kin living in other households. On average, single men brought food to camp on 28% of days, married men without children at home on 31% of days, and married men with children at home on 42% of days. Married men brought fruit, the least widely shared resource, to camp significantly more often than single men. A model of the relationship between hunting success and household food consumption indicates that the best hunters provided 3–4 times the amount of food to their families than median or poor hunters. These new data fill important gaps in our knowledge of the subsistence economy of the Hadza and uphold predictions derived from the household and kin provisioning hypotheses. Key evidence and assumptions backing prior claims that Hadza hunting is largely a form of status competition were not replicated in our study. In light of this, family provisioning is a more viable explanation for why good hunters are preferred as husbands and have higher fertility than others. (shrink)

The foundational principles of representative democracy are under attack globally. What we desperately need are enlightened and persuasive public intellectuals who can help us see through the fog of our fear, anger, and disillusionment, to find our rational political commitments again. One of these public intellectuals is undoubtedly Yuval Noah Harari, the bestselling author of three recent books – Sapiens, Homo Deus, and 21 Lessons for the 21st Century. Harari is also a frequent contributor in the popular press, and a (...) guest on shows, podcasts, panels, and as a keynote speaker. Add to all this that Harari is acting on his lofty academic ideals through ‘Sapienship’, a multidisciplinary organization he cofounded that advocates for global responsibility, clarifies the global conversation, and focuses attention on the most important global challenges. I single out Harari because I presume many readers will be familiar with his work. He is certainly one of the fastest rising stars of public intellectualism. Unfortunately, his work is undercut by the philosophical positions he put forth in his first bestselling book, Sapiens. In this review/critique I wish to show that in order for Harari advance a coherent political or ideological argument, he must first shore up his philosophical commitments. (shrink)

Andrew Webster proposes that science and technology studies align itself more thoroughly with practical policy contexts, actors and issues, so as to become more useful, and thus more a regular actor in such worlds. This commentary raises some questions about this approach. First, I note that manifest influence in science or policy or both should not become-by default, or deliberately-a criterion of intellectual quality for STS research work. I distinguish between reflective historical work, which delineates the contingent ways in which (...) existing policy and technoscientific cultures have become entrenched as such inscribed and perhaps dysfunctional institutional habit; and, work of the kind that Webster's three case studies exemplify, that is, geared to influence policy-decision outcomes. I suggest that many of the important issues facing STS-and "policy"-are not explicit "policy-decision issues" as such, but implicit "policy syndromes" that need naming, diagnosing and open, if enforced, institutional reflection. (shrink)

The old adage has two people out hiking who run into a bear. One starts running while the other asks ‘why are you running? You can’t outrun a bear’. To which the other responds, ‘I don’t have to outrun the bear. I only have to outrun you’. Hiking/trekking is not typically a competitive endeavor characterized by contests but, like many endeavors/pursuits/activities, competition can be injected into it; thereby sportifying it. Swimming is a sport (under certain conditions). At the same time, (...) it is also a recreational activity and a form of physical exercise; likewise angling/fishing, climbing, cross-country skiing, mountain biking, kayaking, rowing, surfing, et al. The categorization of many activities under the umbrella of sport has it uses to understand the wider concept of what is sport, but the purpose of why one engages in ‘physical activities taking place in a natural environment’ can sometimes be more important than whether some activities might or might not qualify to be classified under the rubric of sports at all. Indicators exist to show whether participants are actually engaged toward—driven in a way, even—to further their skills in their focused activity (if it is a focused activity at all!––i.e. a ‘serious leisure’ pursuit or just a recreational hobby). From this perspective (of looking at sport-like and sporting activities in other than Olympic-style forms) this paper explores the differentiations between sport (including nature sport) contests, nature challenge activities (NCAs) and outdoor recreation from the standpoint of the most relevant factors that distinguish them: rules, skill development, purpose for engaging in them. This paper also makes the case that differentiating participants in the above activities by purpose (as either nature challenge recreationalists or nature sport devotees) has utility; to better help research into people’s engagement in physical activities in natural environments. (shrink)

The preface paradox can be motivated by appealing to a plausible inference from an author’s reasonable assertion that her book is bound to contain errors to the author’s rational belief that her book contains errors. By evaluating and undermining the validity of this inference, I offer a resolution of the paradox. Discussions of the preface paradox have surprisingly failed to note that expressions of fallibility made in prefaces typically employ terms such as surely, undoubtedly, and bound to be. After considering (...) what these terms mean, I show that the motivating inference is invalid. Moreover, I argue that a closer consideration of our expressions of fallibility suggest that epistemically responsible authors would not be rational to believe that their books contain errors. I conclude by considering alternative expressions of fallibility that employ terms such as possible and probable, and discuss the role that expressions of fallibility play in conversation. (shrink)

We define prenormal modal logics and show that S1, S1, S0.9, and S0.9 are Lewis versions of certain prenormal logics, determination and decidability for which are immediate. At the end we characterize Cresswell logics and ponder C. I. Lewis's idea of strict implication in S1.

Current COVID-19 pandemic and previous SARS/MERS outbreaks have caused a series of major crises to global public health. We must integrate the large and exponentially growing amount of heterogeneous coronavirus data to better understand coronaviruses and associated disease mechanisms, in the interest of developing effective and safe vaccines and drugs. Ontologies have emerged to play an important role in standard knowledge and data representation, integration, sharing, and analysis. We have initiated the development of the community-based Coronavirus Infectious Disease Ontology (CIDO). (...) As an Open Biomedical Ontology (OBO) library ontology, CIDO is an open source and interoperable with other existing OBO ontologies. In this article, the general architecture and the design patterns of the CIDO are introduced, CIDO representation of coronaviruses, phenotypes, anti-coronavirus drugs and medical devices (e.g. ventilators) are illustrated, and an application of CIDO implemented to identify repurposable drug candidates for effective and safe COVID-19 treatment is presented. (shrink)

Abstract:The standard, Bayesian account of rational belief and decision is often argued to be unable to cope properly with severe uncertainty, of the sort ubiquitous in some areas of policy making. This paper tackles the question of what should replace it as a guide for rational decision making. It defends a recent proposal, which reserves a role for the decision maker’s confidence in beliefs. Beyond being able to cope with severe uncertainty, the account has strong normative credentials on the main (...) fronts typically evoked as relevant for rational belief and decision. It fares particularly well, we argue, in comparison to other prominent non-Bayesian models in the literature. (shrink)

Bell's Theorem is proved for locality and conservation formulated in terms of subjunctive conditionals with chance consequents, rather than the usual conditional probability formulation. This brings into sharp focus the minimal counterfactual assumptions needed for Bell's theorem.

We provide a conceptual framework and a case study of how an organization links its mission and espoused values with its operating practices. Conceptually, we locate this mission integration theme within Simons’ management accounting and control framework, and then adapt Schatzki’s site ontology of social practice to develop general research expectations for case studies of espoused values/practice linkages. Empirically, we apply the conceptual framework to a case study of linkages among an actual company’s espoused values, human resource practices, and financial (...) management during its 40-plus year history. The concluding section summarizes the study and discusses its implications, limitations, and opportunities for future research. (shrink)

This article explores public reason liberalism’s indeterminacy problem, a problem that obtains when we admit significant diversity into our justificatory model. The article argues first that Gerald Gaus’s solution to the indeterminacy problem is unsatisfactory and second that, contra Gaus’s concerns, social choice theory is able to solve public reason’s indeterminacy problem. Moreover, social choice theory can do so in a way that avoids the worries raised against Gaus’s solution to the indeterminacy problem as well as the worries Gaus himself (...) raises against the use of social choice mechanisms. Social choice theory thus rescues public reason liberalism by aggregating out of indeterminacy. (shrink)

When we ask a decision maker to express her preferences, it is typically assumed that we are eliciting a pre-existing set of preferences. However, empirical research has suggested that our preferences are often constructed on the fly for the decision problem at hand. This paper explores the ramifications of this empirical research for our understanding of instrumental rationality. First, I argue that these results pose serious challenges for the traditional decision-theoretic view of instrumental rationality, which demands global coherence amongst all (...) of one's beliefs and desires. To address these challenges, I first develop a minimal notion of instrumental rationality that issues in localized, goal-relative demands of coherence. This minimal conception of instrumental rationality is then used to offer a more sophisticated account of the global aspects of instrumental rationality. The resulting view abandons all-or-nothing assessments of rationality and allows us to evaluate decision makers as being rational to varying degrees. My aim is to propose a theory that is both psychologically and normatively plausible. (shrink)

The structure of Reichenbach's pragmatic vindication of induction is analysed in detail. The argument is seen to proceed in two stages, the first being a pragmatic justification of the frequency interpretation of probability which is taken as a license for considering the aim of induction to be the discovery of limiting relative frequencies, and the second being the pragmatic justification of induction itself. Both justifications are found to contain flaws, and the arguments used to support Reichenbach's definition of the aim (...) of induction presuppose the availability of a type of predicate which generates paradoxes closely related to Goodman's "grue-bleen" paradox. Next, Salmon's "Criterion of Linguistic Invariance" is evaluated as a canon of inductive logic, which singles out the "straight rule" from an infinite class of convergent inductive rules. Upon close examination, its credentials are seen to be unimpressive. In connection with Salmon's work on linguistic invariance, we take a closer look at the impact of the Goodman paradox on probability estimator rules like Reichenbach's "straight rule." We find that its undesirable consequences for such systems of inductive logic cannot be escaped by Salmon's solution, or indeed by any solution whose motivating idea is to rule "queer" predicates out of court. Finally, the discussion of the Goodman paradox leads us to a modest methodological proposal for systems of inductive logic which incorperate probability estimator rules of the type at issue. (shrink)

Since its publication in 1965, Brian Barry's seminal work has occupied an important role in the revival of Anglo-American political philosophy. A number of ideas and terms in it have become part of the standard vocabulary, such as the distinction between "ideal-regarding" and "want-regarding" principles and the division of principles into aggregative and distributive. The book provided the first precise analysis of the concept of political values having trade-off relations and its analysis of the notion of the public interest (...) has also been significant. (shrink)

Daniel Kahneman was not the first to suggest that attention and effort are closely associated, but his 1973 book Attention and Effort, which claimed that attention can be identified with effort, cemented the association as a research paradigm in the cognitive sciences. Since then, the paradigm has rarely been questioned and appears to have set the research agenda so that it is self-reinforcing. In this article, we retrace Kahneman's argument to understand its strengths and weaknesses. The central notion of effort (...) is not clearly defined in the book, so we proceed by constructing the most secure inferences we can from Kahneman's argument regarding effort: it is cognitive, objective, metabolic expenditure, and it is attention. Continuing, we find from Kahneman's argument that effort-attention must be a special case of sympathetic dominance of the autonomic nervous system that is also an increase in metabolic activity in the brain that has crossed a threshold of magnitude. We then weigh this conception of effort against evidence in Kahneman's book and against more recent evidence, finding that it does not warrant the conclusion that effort can be equated with attention. In support of an alternative perspective, we briefly review diverse studies of behavior, physiology and neuroscience on attention and effort, including meditation and studies of the LC-NE system, where we find evidence for the following: 1) Attention seems to be associated not with the utilization of metabolic resources per se but with the readying of metabolic resources in the form of adaptive gain modulation. This occurs under sympathetic dominance and can be experienced as effortful. 2) Attention can also occur under parasympathetic dominance, in which case it is likely experienced as effortless. (shrink)

Rationale: Deep brain stimulation (DBS) of the hippocampus is proposed for enhancement of memory impaired by injury or disease. Many pre-clinical DBS paradigms can be addressed in epilepsy patients undergoing intracranial monitoring for seizure localization, since they already have electrodes implanted in brain areas of interest. Even though epilepsy is usually not a memory disorder targeted by DBS, the studies can nevertheless model other memory-impacting disorders, such as Traumatic Brain Injury (TBI). Methods: Human patients undergoing Phase II invasive monitoring for (...) intractable epilepsy were implanted with depth electrodes capable of recording neurophysiological signals. Subjects performed a delayed-match-to-sample (DMS) memory task while hippocampal ensembles from CA1 and CA3 cell layers were recorded to estimate a multi-input, multi-output (MIMO) model of CA3-to-CA1 neural encoding and a memory decoding model (MDM) to decode memory information from CA3 and CA1 neuronal signals. After model estimation, subjects again performed the DMS task while either MIMO-based or MDM-based patterned stimulation was delivered to CA1 electrode sites during the encoding phase of the DMS trials. Each subject was sorted (post hoc) by prior experience of repeated and/or mild-to-moderate brain injury (RMBI), TBI, or no history (control) and scored for percentage successful delayed recognition (DR) recall on stimulated vs. non-stimulated DMS trials. The subject’s medical history was unknown to the experimenters until after individual subject memory retention results were scored. Results: When examined compared to control subjects, both TBI and RMBI subjects showed increased memory retention in response to both MIMO and MDM-based hippocampal stimulation. Furthermore, effects of stimulation were also greater in subjects who were evaluated as having pre-existing mild-to-moderate memory impairment. Conclusion: These results show that hippocampal stimulation for memory facilitation was more beneficial for subjects who had previously suffered a brain injury (other than epilepsy), compared to control (epilepsy) subjects who had not suffered a brain injury. This study demonstrates that the epilepsy/intracranial recording model can be extended to test the ability of DBS to restore memory function in subjects who previously suffered a brain injury other than epilepsy, and support further investigation into the beneficial effect of DBS in TBI patients. (shrink)

Universities are seldom lauded publicly for maintaining good processes and practices; instead, media stories commonly focus on shortcomings. Furthermore, universities, even when doing everything right, sometimes are unfairly targeted for criticism in circumstances in which making a public defence is difficult. A prominent case at the University of Wollongong shows how defending a university’s integrity can be hampered by confidentiality requirements, lack of public understanding of thesis examination processes and of disciplinary expectations, and university procedures not designed for extraordinary attacks. (...) The implication is that there can be value in fostering greater awareness of the ways that universities and disciplinary fields operate, and reconsidering procedures with an eye towards possible attacks, both external and internal. (shrink)

There has been extensive work in the space of Indigenous epistemological approaches to research. Because Australian Indigenous peoples have been researched significantly, there are guidelines around the ethical and cultural conduct of this type of research. Via investigating the Academy’s approach to research in general, we can illuminate the vast differences between empirical approaches to research from the ‘West’ compared to knowledge acquisition and sharing through ‘relationality’ from an Indigenous perspective. This paper investigates this dichotomy and brings into question the (...) premise of power and value attributed to each approach, arguing that this is still not an equal ascription. This paper posits a reconfiguration of approaches to research as a way of extending on research in general, and provides a platform of how Indigenous knowledges can extend on and reconfigure, in a positive way, approaches to research. (shrink)

COVID-19 often manifests with different outcomes in different patients, highlighting the complexity of the host-pathogen interactions involved in manifestations of the disease at the molecular and cellular levels. In this paper, we propose a set of postulates and a framework for systematically understanding complex molecular host-pathogen interaction networks. Specifically, we first propose four host-pathogen interaction (HPI) postulates as the basis for understanding molecular and cellular host-pathogen interactions and their relations to disease outcomes. These four postulates cover the evolutionary dispositions involved (...) in HPIs, the dynamic nature of HPI outcomes, roles that HPI components may occupy leading to such outcomes, and HPI checkpoints that are critical for specific disease outcomes. Based on these postulates, an HPI Postulate and Ontology (HPIPO) framework is proposed to apply interoperable ontologies to systematically model and represent various granular details and knowledge within the scope of the HPI postulates, in a way that will support AI-ready data standardization, sharing, integration, and analysis. As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occurring at critical host-coronavirus interaction checkpoints. Furthermore, the host-coronavirus protein-protein interactions (PPIs) relevant to COVID-19 were predicted and evaluated based on prior knowledge of curated PPIs and domain-domain interactions, and how such studies can be further explored with the HPI postulates and the HPIPO framework is discussed. (shrink)

Drawing on interviews and observational work with practicing U.K. plant scientists, this article uses Michel Callon's work as a tool to explore the issue of collaboration between academic science and business, in particular, calls by the Biotechnology and Biological Sciences Research Council for a return to “public good” plant science. In an article titled “Is Science a Public Good?” Callon contributed to the debate about the commercialization of science by suggesting that commercialization and the public good need not be incompatible. (...) Moving away from arguments that center on the effects of business involvement in science, he suggested that analysts use another model, centered on “diversity.” This model allows us to ask what society might want from science, what public good science might look like, and how public good science can be ensured while also recognizing that science cannot be easily separated from the market. (shrink)